Most Active AI Investors in San Francisco 2026
| # | Investor | AI Deals | Lead | Representative Portfolio |
|---|---|---|---|---|
| 1 | Andreessen Horowitz | 28 | 17 | Databricks, xAI, Replit, OpenAI, Cursor |
| 2 | Sequoia Capital | 20 | 12 | Anthropic, xAI, OpenAI, Juicebox, Harvey |
| 3 | Y Combinator | 18 | 2 | Scale AI, AgentMail, Juicebox, Trayd, Glimpse |
| 4 | Lightspeed Venture Partners | 17 | 10 | Anthropic, Glean, Isembard, Stacks, Kana Intelligence |
| 5 | Khosla Ventures | 15 | 9 | OpenAI, Glean, Replit, Rhoda, Glydways |
| 6 | Thrive Capital | 14 | 8 | OpenAI, Databricks, Perplexity, Cursor, Rogo |
| 7 | General Catalyst | 13 | 7 | AgentMail, Stacks, Cloaked, Doss, Musely |
| 8 | Kleiner Perkins | 12 | 8 | Eridu, Health Universe, Harvey, Rogo, Parallel Web Systems |
| 9 | Accel | 11 | 8 | Scale AI, Cursor, Mind Robotics, Ciridae, Viktor |
| 10 | Google Ventures (GV) | 10 | 3 | Anthropic, Replit, Sierra, MokN, Flourish |
| 11 | NVIDIA | 10 | 2 | Databricks, xAI, Inflection AI, World Labs, Firmus |
| 12 | Index Ventures | 7 | 3 | Scale AI, Parallel Web Systems, Cowboy Space, Nourish, Uncovr |
| 13 | Spark Capital | 7 | 3 | Anthropic, Parallel Web Systems, Mercury, Generalist AI, Baseten |
| 14 | Antler | 7 | 2 | First Concepts, Endform, Stendr, Alcolase, Perplant |
| 15 | Seedcamp | 6 | 2 | Omniscient, Spektr, Prelude, Apoha, Uncovr |
How this ranking is calculated
Investors are ranked by the number of tracked AI funding rounds matching this angle (15 investors shown, 195 qualifying deals total). Rankings are computed directly from publicly reported rounds in our database and update as new deals are added. The “undisclosed” placeholder is excluded. Ties break by lead-investor count. Placement cannot be purchased.