Most Active AI Investors in San Francisco 2026
| # | Investor | AI Deals | Lead | Representative Portfolio |
|---|---|---|---|---|
| 1 | Andreessen Horowitz | 29 | 18 | Databricks, xAI, Replit, OpenAI, Cursor |
| 2 | Sequoia Capital | 22 | 13 | Anthropic, xAI, OpenAI, Juicebox, Harvey |
| 3 | Y Combinator | 21 | 4 | AgentMail, Juicebox, Trayd, Glimpse, Scale AI |
| 4 | Lightspeed Venture Partners | 16 | 10 | Anthropic, Glean, Isembard, Stacks, Kana Intelligence |
| 5 | General Catalyst | 16 | 9 | AgentMail, Stacks, Cloaked, Doss, Musely |
| 6 | Khosla Ventures | 15 | 9 | Glean, Replit, Rhoda, OpenAI, Glydways |
| 7 | Thrive Capital | 14 | 8 | Databricks, Perplexity, OpenAI, Cursor, Rogo |
| 8 | Accel | 13 | 10 | Scale AI, Cursor, Mind Robotics, Ciridae, Circle |
| 9 | Kleiner Perkins | 12 | 8 | Eridu, Health Universe, Harvey, Rogo, Parallel Web Systems |
| 10 | NVIDIA | 11 | 3 | Databricks, xAI, Inflection AI, World Labs, Firmus |
| 11 | Google Ventures (GV) | 10 | 3 | Anthropic, Replit, Sierra, MokN, Flourish |
| 12 | Spark Capital | 9 | 5 | Anthropic, Parallel Web Systems, Mercury, Generalist AI, Baseten |
| 13 | Index Ventures | 8 | 4 | Scale AI, Parallel Web Systems, Cowboy Space, Nourish, Uncovr |
| 14 | Menlo Ventures | 6 | 5 | Anthropic, Arc Boat Company, Gimlet Labs, Nectar Social, Nourish |
| 15 | Eclipse | 6 | 3 | Arc Boat Company, Gimlet Labs, True Anomaly, Mind Robotics, Cellares |
How this ranking is calculated
Investors are ranked by the number of tracked AI funding rounds matching this angle (15 investors shown, 208 qualifying deals total). Rankings are computed directly from publicly reported rounds in our database and update as new deals are added. The “undisclosed” placeholder is excluded. Ties break by lead-investor count. Placement cannot be purchased.
Data through Sep 8, 2026. Refreshed daily as new funding rounds are ingested and the site redeploys.